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  3. S-Adenosylmethionine (SAMe)
S-Adenosylmethionine (SAMe)
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S-Adenosylmethionine (SAMe)

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This is a drug monograph from the BSAVA Small Animal Formulary Part A: Canine and Feline. BSAVA members should login for access to the full monograph. Non-members can join BSAVA, buy a Formulary subscription, or buy the printed edition. 
  1. Skorupski KA ,Hammond GM ,Irish AM et al. (2011)Prospective randomized clinical trial assessing the efficacy of Denamarin for prevention of CCNU-induced hepatopathy in tumor-bearing dogs. Journal of Veterinary Internal Medicine 25 ,838–845
  2. Vandeweerd JM ,Cambier C andGustin P (2013)Nutraceuticals for canine liver disease: assessing the evidence. Veterinary Clinics of North America: Small Animal Practice 43 ,1171–1179
  3. Au AY, Hasenwinkel JM and Frondoza CG (2013) Hepatoprotective effects of S-adenosylmethionine and silybin on canine hepatocytes in vitro.Journal of Animal Physiology and Animal Nutrition (Berl) 97, 331 – 341
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  4. Center SA, Randolph JF, Warner KL et al. (2005) The effects of S-adenosylmethionine on clinical pathology and redox potential in the red blood cell, liver, and bile of clinically normal cats.Journal of Veterinary Internal Medicine 19, 303 – 314
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  5. Center SA, Warner KL, McCabe J et al. (2005) Evaluation of the influence of S-adenosylmethionine on systemic and hepatic effects of prednisolone in dogs.American Journal of Veterinary Research 66, 330 – 341
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  6. Hagen DM, Ekena JL, Geesaman BM and Viviano KR (2019) Antioxidant supplementation during illness in dogs: effect on oxidative stress and outcome, an exploratory study.Journal of Small Anim Practice 60, 543 – 550
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  7. Reme CA, Dramard V, Kern L et al. (2008) Effect of S-adenosylmethionine tablets on the reduction of age-related mental decline in dogs: a double-blinded, placebo-controlled trial.Veterinary Therapeutics 9, 69 – 82
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  8. Imhoff DJ, Gordon-Evans WJ, Evans RB et al. (2011) Evaluation of S-adenosyl l-methionine in a double-blinded, randomized, placebo-controlled, clinical trial for treatment of presumptive osteoarthritis in the dog.Veterinary Surgery 40, 228–232
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  9. Wallace KP, Center SA, Hickford FH, Warner KL and Smith S (2002) S-adenosyl-L-methionine (SAMe) for the treatment of acetaminophen toxicity in a dog.Journal of the American Animal Hospital Association 38, 246 – 254
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  10. Webb CB, Twedt DC, Fettman MJ and Mason G (2003) S-adenosylmethionine (SAMe) in a feline acetaminophen model of oxidative injury.Journal of Feline Medicine and Surgery 5, 69–75
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  11. Webster CR and Cooper J (2009) Therapeutic use of cytoprotective agents in canine and feline hepatobiliary disease. V eterinary Clinics of North America: Small Animal Practice 39, 631 –6 52
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