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Canine hyperthyroidism and thyroid neoplasia

image of Canine hyperthyroidism and thyroid neoplasia
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Abstract

This chapter discusses hyperthyroidism in dogs and considers both functional thyroid neoplasia and dietary thyrotoxicosis. It covers the classification and pathogenesis of thyroid tumours in dogs, as well as their clinical features, diagnosis and treatment. It emphasizes the importance of thorough staging and evaluation of local invasiveness and metastases to determine the most appropriate treatment. Surgical excision, radiation therapy, and radioactive iodine therapy are discussed as potential treatment options, along with their associated outcomes. Chemotherapy and other emerging treatments, such as toceranib phosphate, are also considered. Prognostic factors and the overall prognosis for dogs with thyroid tumours are also discussed.

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Figures

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20.1 Fine-needle aspiration sample of a canine thyroid tumour interpreted as carcinoma, showing a sheet of neoplastic epithelial cells with indistinct cell borders and moderate anisocytosis and anisokaryosis. Note the mitotic prophase (arrowed). (Modified Wright’s stain, X50 oil objective lens) (Courtesy of Laureen Peters, Department of Clinical Veterinary Science, University of Bern)
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20.3 (a) Ultrasonographic image (transverse view) of a right-sided thyroid tumour in a 12-year-old male terrier cross. It measured 1.2 cm in width and 3.38 cm in length. (b) The tumour elicited significant Doppler signal. (Courtesy of University College Dublin)
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20.4 Computed tomographic image (transverse view) of a left-sided thyroid tumour in a dog (arrowed). (Courtesy of the Department of Medical Imaging, University of Bern)
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20.5 Ventrodorsal view of a thyroid pertechnetate scan of a dog with bilateral follicular thyroid carcinomas. The right-sided tumour presents a heterogeneous uptake pattern while the left-sided tumour exhibits a homogeneous uptake. (Courtesy of the Department of Veterinary Medical Imaging and Small Animal Orthopaedics, University of Ghent)
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20.6 Ventrodorsal view of a thyroid planar pertechnetate scan of a dog with ectopic sublingual follicular cell thyroid neoplasia with a homogeneous uptake pattern. (Courtesy of the Department of Veterinary Medical Imaging and Small Animal Orthopaedics, University of Ghent)
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20.7 Pertechnetate single-photon emission computed tomography (SPECT) of a dog with a follicular thyroid tumour showing two thoracic metastases (arrowed). (Courtesy of the Department of Veterinary Medical Imaging and Small Animal Orthopaedics, University of Ghent)
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20.8 Intraoperative image of a well encapsulated thyroid carcinoma in a dog that had gross evidence of vascular invasion and tumour thrombi within the cranial and caudal thyroid veins (arrowed). (Reproduced from with permission from the publisher)
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20.9 Histological image of a canine thyroid tumour showing vascular invasion (arrowed).
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