1887

Canine hypothyroidism

image of Canine hypothyroidism
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Abstract

Hypothyroidism is considered a common endocrine disorder of dogs. Over the past few decades, significant advances have been made in recognizing the type of dog affected and the expected clinical and clinicopathological features, and in the performance and accuracy of endocrine tests for diagnosis. Despite this, hypothyroidism can be challenging to diagnose and many myths have persisted regarding its associations and consequences. On the other hand, if appropriately diagnosed, hypothyroidism is one of the most satisfying endocrine disorders to treat, with an excellent long-term prognosis.

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Figures

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18.1 Control of thyroid function. T3 = triiodothyronine; T4 = thyroxine; TRH = thyrotropin-releasing hormone; TSH = thyroid-stimulating hormone; = stimulation; = inhibition.
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18.2 (a) Histological section of a healthy canine thyroid gland. (b) Histopathological section of a canine thyroid gland with lymphocytic thyroiditis. Note the inflammatory component replacing normal thyroid tissue. (c) Histopathological section of a canine thyroid gland with idiopathic thyroid atrophy. Note the loss of normal thyroid parenchyma without an inflammatory component. (Haematoxylin and eosin stain; original magnification X100)
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18.4 A 5-month-old male German Shepherd Dog with disproportionate dwarfism as a consequence of congenital hypothyroidism. Note the short legs, broad trunk and wide skull.
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18.6 The hair loss of hypothyroidism typically begins in areas of friction such as (a) the neck in dogs that wear collars and (b) the tail (‘rat tail’).
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18.7 Truncal alopecia with hyperpigmentation in a hypothyroid dog.
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18.8 Nasal alopecia in a hypothyroid dog.
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18.9 Tragic facial expression associated with hypothyroidism.
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18.10 Excess wear of the middle digits in the forelimb of a dog with hypothyroidism, presumably as a consequence of a neuropathy or myopathy.
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18.11 Corneal lipidosis associated with hypothyroidism.
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18.12 Diagnostic algorithm for hypothyroidism. cTSH = canine thyroid-stimulating hormone; NTI = non-thyroidal illness; T4 = thyroxine; TgAA = thyroglobulin autoantibody.
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18.21 Lateral lumbar spinal radiograph in a dog with disproportionate dwarfism associated with congenital hypothyroidism. Note the shortened vertebral bodies with scalloped ventral borders.
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18.22 Cross-sectional ultrasonogram of the thyroid gland in a euthyroid dog. It is triangular in shape, homogeneous and hyperechoic compared with adjacent muscle.
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18.23 Thyroid scintigraphy images in (a) euthyroidism and (b) hypothyroidism. Thyroidal uptake measurements were 0.5% and 0.05% (reference interval 0.39–1.86%). Uptake is also noted in the salivary glands at the level of the ears.
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18.24 Schematic representation of the steps in a therapeutic trial for diagnosing hypothyroidism. cTSH = canine thyroid-stimulating hormone; T4 = thyroxine.
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18.25 Appearance of a hypothyroid dog (a) before and (b) after thyroid hormone replacement therapy.
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