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Concurrent endocrine neoplasia
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Concurrent endocrine neoplasia
- Author: Sara Galac
- From: BSAVA Manual of Canine and Feline Endocrinology
- Item: Chapter 35, pp 331 - 335
- DOI: 10.22233/9781910443866.35
- Copyright: © 2023 British Small Animal Veterinary Association
- Publication Date: August 2023
Abstract
Concurrent endocrine neoplasia (CEN) refers to the simultaneous occurrence of two or more endocrine tumours in animals. The various types of multiple endocrine neoplasia (MEN) in humans are explained, together with the prevalence and genetic mutations associated with MEN syndromes in humans. In dogs, concurrent adrenomedullary, adrenocortical and/or pituitary gland pathology is the most commonly described CEN; in cats, the thyroid gland is the most frequently affected endocrine organ in CEN. The chapter describes the histopathology and clinical presentation of various endocrine tumours. Thorough clinical assessment and screening for CEN are required in order to develop effective treatment plans and improve the quality of life for affected animals.
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35.2
A 10-year-old neutered male Boston Terrier diagnosed with pituitary adenoma, phaeochromocytoma and paraganglioma. (ai) A computed tomographic image of the head demonstrated an enlarged pituitary gland (arrowed). (aii) An acidophil pituitary adenoma was diagnosed by histopathology. (bi) On abdominal CT, bilateral adrenomegaly was noted (arrow = left adrenal gland, arrowhead = right adrenal gland). (bii) Ingrowth of the right phaeochromocytoma into the adrenal capsule was present (arrowed) and (biii) nodular hyperplasia was detected in the left adrenal gland cortex (arrowheads). (ci) A mass was found on the heart base (arrowed). (cii) Histopathology revealed a paraganglioma. © 2023 British Small Animal Veterinary Association
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35.2
A 10-year-old neutered male Boston Terrier diagnosed with pituitary adenoma, phaeochromocytoma and paraganglioma. (ai) A computed tomographic image of the head demonstrated an enlarged pituitary gland (arrowed). (aii) An acidophil pituitary adenoma was diagnosed by histopathology. (bi) On abdominal CT, bilateral adrenomegaly was noted (arrow = left adrenal gland, arrowhead = right adrenal gland). (bii) Ingrowth of the right phaeochromocytoma into the adrenal capsule was present (arrowed) and (biii) nodular hyperplasia was detected in the left adrenal gland cortex (arrowheads). (ci) A mass was found on the heart base (arrowed). (cii) Histopathology revealed a paraganglioma.