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Hypersomatotropism
/content/chapter/10.22233/9781910443866.chap13
Hypersomatotropism
- Author: Stijn Niessen
- From: BSAVA Manual of Canine and Feline Endocrinology
- Item: Chapter 13, pp 89 - 96
- DOI: 10.22233/9781910443866.13
- Copyright: © 2023 British Small Animal Veterinary Association
- Publication Date: August 2023
Abstract
Hypersomatotropism is an endocrine disorder characterized by excess production of growth hormone (GH) in dogs and cats. This chapter discusses the synthesis, regulation and functions of GH, as well as its role in insulin resistance and diabetes mellitus. It explores the different aetiologies of hypersomatotropism in dogs and cats, including excess progesterone, genetic factors, and environmental contaminants. The clinical features, diagnosis, and differential diagnoses of hypersomatotropism are described, along with various treatment options such as hypophysectomy, medical therapy and radiotherapy. The prognosis and treatment outcomes are also discussed.
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Figures
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13.2
Mandibular enlargement resulting in prognathism and thickening of the bony ridges of the skull in a cat with hypersomatotropism. While a typical finding, this is not seen in all cats with hypersomatotropism. © 2023 British Small Animal Veterinary Association
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13.2
Mandibular enlargement resulting in prognathism and thickening of the bony ridges of the skull in a cat with hypersomatotropism. While a typical finding, this is not seen in all cats with hypersomatotropism.
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13.3
Widening of interdental spaces due to chronic exposure to excess growth hormone in a dog with hypersomatotropism. © 2023 British Small Animal Veterinary Association
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13.3
Widening of interdental spaces due to chronic exposure to excess growth hormone in a dog with hypersomatotropism.
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13.4
Cross-section of the heart from a cat with hypersomatotropism, showing generalized myocardial hypertrophy. © 2023 British Small Animal Veterinary Association
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13.4
Cross-section of the heart from a cat with hypersomatotropism, showing generalized myocardial hypertrophy.
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13.5
Macroscopic abnormalities, specifically pancreatic enlargement and cysts, in a pancreas from a cat with hypersomatotropism. © 2023 British Small Animal Veterinary Association
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13.5
Macroscopic abnormalities, specifically pancreatic enlargement and cysts, in a pancreas from a cat with hypersomatotropism.
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13.6
Post-mortem examination and computed tomographic findings in a cat with hypersomatotropism. The white arrows indicate the enlarged pituitary gland. The black arrow indicates the optic chiasm, illustrating the potential, albeit rare, for visual abnormalities to occur when a large pituitary tumour is present. © 2023 British Small Animal Veterinary Association
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13.6
Post-mortem examination and computed tomographic findings in a cat with hypersomatotropism. The white arrows indicate the enlarged pituitary gland. The black arrow indicates the optic chiasm, illustrating the potential, albeit rare, for visual abnormalities to occur when a large pituitary tumour is present.