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Recent advantages in the monitoring, management and pharmacological treatment of critically ill animals with gastrointestinal (GI) diseases have enhanced the chances of survival. The goals of the intensive care unit (ICO) patient care team are to provide excellent monitoring and nursing care, and to prevent complications that result from anorexia, inactivity, the presence of invasive lines (i.e. catheters, feeding tubes, chest tubes, etc.) and from the primary disease itself. This chapter explains Role of the gut in multiple organ failure; General supportive measures; and Specific disorders.