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Oral disease is a common problem of dogs and cats of all ages. An oral examination is a very important part of every physical examination. Some abnormality of the oral cavity is usually found when a dog or cat’s mouth is examined. Clinical signs of oral disease vary depending on the underlying problem. A problem in the oral cavity should be suspected and ruled out for any dog or cat showing evidence of oral pain, difficulty eating, interest in food but reluctance to eat, excessive salivation, facial swellings or draining fistulas, halitosis or bleeding from the oral cavity. This chapter informs on Peridontal disease and Disorders of the oral cavity.