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Laboratory evaluation of joint disease is based on examination of synovial fluid. Synovial fluid analysis rarely yields a definitive aetiological diagnosis but it does help to confirm the presence of an arthropathy, to discriminate between broad categories of joint disease, and to guide the choice of further tests (e.g. serology, culture, polymerase chain reaction (PCR), antinuclear antibody titre, rheumatoid factor titre, etc.). This chapter considers physiology and composition, pathogenesis of joint effusion, indications and contraindications for arthrocentesis, arthrocentesis technique, synovial fluid analysis and further tests. Case examples can be found at the end of this section.
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Laboratory evaluation of joint disease, Page 1 of 1
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